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keywords
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Bioinformatics, Single-cell RNA sequencing, Cancer Immunotherapy, Spatial Transcriptomics
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overview
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I am an Assistant Professor of Bioinformatics in the Department of Cancer Biology, Wake Forest School of Medicine, and currently a Full Member of Bioinformatics Shared Resources at the Wake Forest Baptist Comprehensive Cancer Center. I have been studying clinical genetics in cancer treatments and single-cell genomics in cancer immunotherapy. My team has pioneered work in single-cell modeling of response to checkpoint immunotherapy and developed an innovative projection-free single-cell modeling algorithm for this field. My current research focuses are the roles of CAR T cells in inducing neurotoxicity associated with CAR-T cell therapies, genetic biomarkers for surgical outcomes in appendiceal cancer, and genetics-level understanding of the SARS-CoV-2 variants. Our lab published over 40 papers in this field (i10-index=29, h-index=20). Our papers published in high-impact journals, including Cancer Cell, Lancet Oncology, JAMA Oncology, Nature Communications, Nature Biomedical Engineering, Briefings of Bioinformatics, etc. Our collaborating projects have been well funded by NIH/NCI, DoD, and other federal funding agencies. Our lab has a long-term interest in developing novel computational methods for sequencing analysis and their application to translational and clinical research.
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